产品货号：
Z35932
中文名称：
POU2AF1抗体
英文名称：
Anti-POU2AF1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-POU2AF1 Antibody |
| 指标别名 | POU domain class 2-associating factor 1;B-cell-specific coactivator OBF-1;BOB-1;OCA-B;OCT-binding factor 1;POU2AF1;OBF1 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | POU2AF1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human BOB1 Transcriptional coactivator that specifically associates with either OCT1 or OCT2.It boosts the OCT1 mediated promoter activity and to a lesser extent,that of OCT2.It has no intrinsic DNA-binding activity.It recognizes the POU domains of OCT1 and OCT2.It is essential for the response of B-cells to antigens and required for the formation of germinal centers. |
| 实际分子量 | 35KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | POU2AF1(POU domain class 2-associating factor 1),also known as OBF1,BOB1 and OCAB,is a protein that in humans is encoded by the POU2AF1 gene.POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables them to adopt various monomer configurations on DNA.The versatility of POU protein operation is additionally conferred at the dimerization level.Casellas et al.(2002) reported that OCAB is essential for V(D)J recombination of a subset of Ig-kappa genes.They showed that OCAB modulates recombination by directly enhancing Ig-kappa gene transcription in vivo.Siegel et al.(2006) suggested that,together with dysregulation of other OCAB target genes,altered regulation of SYK may help explain the magnitude of defects observed in B-cell development,including the pre-B1-to-pre-B2 transition,and immune responses in Ocab -/- mice. |
| Uniprot ID | Q16633 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
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